General Information

  • ID:  hor000650
  • Uniprot ID:  P31799
  • Protein name:  Locustamyoinhibiting peptide
  • Gene name:  NA
  • Organism:  Locusta migratoria (Migratory locust)
  • Family:  Allatostatin family
  • Source:  Animal
  • Expression:  Neurons located in two ventral cell clusters in the subesophageal ganglion.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  AWQDLNAGW
  • Length:  9(1-9)
  • Propeptide:  AWQDLNAGW
  • Signal peptide:  NA
  • Modification:  T9 Tryptophan amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Suppresses spontaneous contractions of the hindgut and oviduct.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000650_AF2.pdbhor000650_ESM.pdb

Physical Information

Mass: 120303 Formula: C49H65N13O14
Absent amino acids: CEFHIKMPRSTVY Common amino acids: AW
pI: 3.75 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 5
Hydrophobicity: -58.89 Boman Index: -676
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 65.56
Instability Index: 4400 Extinction Coefficient cystines: 11000
Absorbance 280nm: 1375

Literature

  • PubMed ID:  1796179
  • Title:  Isolation, identification and synthesis of locustamyoinhibiting peptide (LOM-MIP), a novel biologically active neuropeptide from Locusta migratoria.